Oral metronidazole continues to be described to potenti-ate the anticoagulant impact of coumarin and warfarin leading to a prolongation of prothrombin time. The effect of topical metronida-zole on prothrombin time will not be identified.
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Metronidazole has shown proof of carcinogenic exercise in reports involving chronic oral administration in mice and rats, but not in experiments involving hamsters. In various lengthy-expression research in mice, oral doses of close to 225 mg/m2/day or increased ended up related to an increase in pulmonary tumors and lymphomas. Quite a few lengthy-phrase oral experiments within the rat have shown statistically important improves in mammary and hepatic tumors at doses >885 mg/m2/working day. Metronidazole has demonstrated proof of mutagenic activity in numerous in vitro bacterial assay programs.
The looks of abnormal neurologic symptoms requires the prompt discontinuation of metronidazole vaginal gel therapy. Metronidazole vaginal gel really should be administered with warning to patients with central anxious method conditions.
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This possible drug conversation ought to be thought of when metronidazole vaginal gel is prescribed for sufferers on such a anticoagulant therapy.